CHANGES IN THE LEVEL OF TROPHOBLASTIC ß-GLYCOPROTEIN IN IVF PREGNANCIES COMPLICATED BY MISCARRIAGE

Abstract

This study evaluated the level of trophoblastic ß-glycoprotein (TBG) in 143 pregnant women who conceived via in vitro fertilization (IVF) and experienced miscarriage. A significant decrease in TBG levels was identified as the most critical risk factor: when TBG levels dropped fivefold or more, the probability of spontaneous pregnancy loss reached 100%. When TBG levels decreased by 2–4 times, the risk of miscarriage was 30–33%. The level of trophoblastic ß-glycoprotein (TBG) was assessed in the development of miscarriage in 143 pregnant women with IVF. The most dangerous is a sharp decrease in the level of TBG: if the indicators have decreased by 5 times or more, the probability of spontaneous termination of pregnancy is 100%. If the TBG indicator is reduced by 2-4 times, the probability of interruption is 30-33%. Early diagnosis and prognosis of pregnancy complications are essential for determining the management strategy in IVF patients. Among various markers of gestational complications, trophoblastic beta-1-glycoprotein (TBG) plays a significant role. TBG is a member of the pregnancy-specific glycoprotein (PSG) family and is produced by the syncytiotrophoblast layer and placental cells. Predicting miscarriage risk in IVF pregnancies and implementing preventive measures may reduce the incidence of preterm birth as well as perinatal morbidity and mortality.